Efektivitas Paparan Hipoksia Berdasarkan Aktivitas Antioksidan Katalase dan Kadar Malondialdehyde (MDA) Sebagai Indikator Pada Jaringan Jantung Tikus

Abstract

Free radicals can cause oxidative stress, due to an imbalance between oxidants and antioxidants that have the potential to cause cell damage. Free radicals can increase lipid peroxidation, which breaks down into malondialdehyde (MDA) in the blood. MDA is a marker of cellular defects caused by free radicals. In this study, rats were treated with hypoxia in a hypoxia chamber with a concentration of 10% oxygen and 90% nitrogen. Based on the results of statistical tests, the levels of MDA in the liver tissue of rats with catalase activity were Accept H0 i.e. there was no difference in the average duration of exposure to O2 gas. This event can occur because an organism will try to maintain its life when environmental conditions are not favorable. In this study, the effect of continued hypoxia on catalase as an endogenous antioxidant that produces malondialdehyde (MDA) was not found. The results of this study indicate that exposure to hypoxia can reduce the value of pH, pCO2 and pO2 of rat bloodplasma.